Epithalon (5mg, 10mg, 50mg)

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin, a natural polypeptide extract from the pineal gland. It was developed and extensively studied by the St. Petersburg Institute of Bioregulation and Gerontology, primarily by Professor Vladimir Khavinson and colleagues, across more than three decades of research into biological ageing, telomere biology, and pineal gland function.

What Is Epithalon?

Epithalon is a tetrapeptide bioregulator — part of a class of short peptides studied for their role in regulating gene expression in specific tissues. Bioregulator peptides, as developed and categorised by the St. Petersburg Institute, are distinguished by their tissue-specific regulatory activity at very low concentrations, operating through mechanisms distinct from hormone receptor agonism.

The research origins of Epithalon are specifically in pineal gland biology. The pineal gland’s role in melatonin synthesis and circadian regulation has long been associated with ageing processes, and Epithalamin (the natural polypeptide from which Epithalon is derived) was the subject of Soviet-era longevity research in the 1970s–1990s that formed the foundation for Epithalon’s development.

Epithalon Research Background

Telomerase activation research: The most widely cited area of Epithalon research involves telomere biology. Studies by Khavinson et al. documented Epithalon-induced activation of telomerase (the enzyme responsible for telomere maintenance and extension) in human somatic cells in vitro. Telomere shortening is a well-established biomarker of cellular ageing, and telomerase activation is a primary target in longevity research. These findings have made Epithalon one of the most studied peptides in the geroscience field.

Lifespan extension in animal models: Multiple studies in rodent models have examined Epithalon’s effects on lifespan. Research from the St. Petersburg Institute documented mean and maximum lifespan extension in mice and rats administered Epithalon, alongside preservation of antioxidant enzyme activity and retardation of age-related pathological changes.

Melatonin and pineal research: Epithalon has been studied for its effects on melatonin synthesis and pineal gland function in aged animals, with research documenting restoration of melatonin production patterns that decline with age in preclinical models.

Oncological research: A substantial body of Epithalon research has examined its effects in cancer models, with preclinical studies investigating its effects on tumour development and growth in rodent cancer models. This research is distinct from and should not be conflated with any therapeutic application.

Retinal research: Studies have examined Epithalon’s effects in models of retinal degeneration, with researchers documenting preservation of photoreceptor function in aged animal models.

Epithalon in the Longevity Research Stack

Epithalon is among the most studied bioregulator peptides for longevity research applications. It is frequently studied alongside GHK-Cu, MOTS-C, and NAD+ in research programmes examining multiple hallmarks of ageing simultaneously. The tetrapeptide’s small size, stability, and the depth of its published research base make it a reference compound in geroscience research.

Reconstitution Guidelines (Research Use)

Epithalon is supplied as lyophilised powder. Reconstitute with bacteriostatic water.

Recommended concentration: 1mg/ml.

For precise volume calculations: Peptide Reconstitution Calculator

Storage

• Lyophilised powder: 2–8°C, protected from light
• Reconstituted: 2–8°C, use within 28 days
• Long-term: -20°C

VITALITY CARTEL Epithalon

99%+ purity, third-party HPLC verified. CoA available on request. Domestic AU dispatch.