Melanotan 2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide derived from pro-opiomelanocortin (POMC). It is a cyclic heptapeptide that acts as a non-selective agonist at melanocortin receptors (MC1R, MC3R, MC4R, MC5R), studied for its effects on melanogenesis, sexual function, and appetite regulation.

What Is Melanotan 2?

Melanotan 2 was first developed at the University of Arizona. Its predecessor Melanotan I (afamelanotide) has been approved in some jurisdictions as a therapeutic agent for erythropoietic protoporphyria (Scenesse®). Melanotan 2 differs in its broader receptor affinity profile and activity at MC4R — the basis for its study in research areas beyond melanogenesis.

Melanotan 2 Research Background

Melanogenesis research: MT-2’s primary studied mechanism involves activation of MC1R on melanocytes, stimulating melanin production. Preclinical studies in rodent models have documented increased skin pigmentation following administration.

Sexual function research: MT-2’s activity at MC4R receptors in the hypothalamus has made it a subject of sexual function research. The compound PT-141 (bremelanotide) was developed directly from MT-2 research and has since received FDA approval for HSDD in women.

Appetite and metabolic research: MC4R agonism has been associated with appetite suppression in animal models — an active area of investigation in obesity pharmacology.

Photoprotection research: MT-2 has been studied in models of UV-induced skin damage as a potential photoprotective agent.

Reconstitution & Storage

Reconstitute with BAC water. Concentration: 1mg/ml.
Lyophilised: 2–8°C protected from light | Reconstituted: 2–8°C up to 28 days | Long-term: -20°C | Sensitive to light — store in amber vials if possible.

Peptide Reconstitution Calculator

99%+ purity, HPLC verified. CoA available on request. Domestic AU dispatch.